MULTIPLE GASTRIC CARCINOIDS AND PITUITARY-ADENOMA IN TYPE-A GASTRITIS

A 48-year-old male with type A atrophic gastritis developed multiple g astric carcinoids and a pituitary adenoma, Laboratory tests revealed h igh levels of serum gastrin and growth hormone (GH), He underwent subt otal gastrectomy, resulting in a return of the previously elevated gas trin level to normal, Serum GH concentration remained high, Three mont hs after the surgery, the pituitary tumor, composed greatly of GH-immu noreactive cells, was partially removed, Since hypergastrinemia plays a pivotal role in gastric carcinoid formation and induces GH-releasing factor (GHRH) release resulting in GH-producing pituitary tumor forma tion, GH-producing pituitary adenoma might be a clinical manifestation in type A gastritis.