A 31-year-old woman was admitted because of persistent remittent fever
. Tricuspid valve endocarditis due to Staphylococcus aureus was identi
fied as the cause of fever, The patient had no history of intravenous
drug abuse, oral contraceptives or predisposing cardiac disease, Huge
hepatomegaly was found without any signs of congestive heart failure,
Liver enzyme abnormalities were not detected throughout the entire cou
rse of therapy, The liver biopsy specimen revealed peliosis hepatis. T
reatment with panipenem/betamipron was successful, although recurrent
septic pulmonary embolism occurred, The cause of the huge hepatomegaly
encountered in the present case may be attributable to peliosis due t
o severe infection.