CAN PRENYLCYSTEINES BE EXPLOITED AS LIGANDS FOR MAMMALIAN MULTIDRUG-RESISTANCE TRANSPORTERS

Authors
HURWITZ LM CASEY PJ
Citation
Lm. Hurwitz et Pj. Casey, CAN PRENYLCYSTEINES BE EXPLOITED AS LIGANDS FOR MAMMALIAN MULTIDRUG-RESISTANCE TRANSPORTERS, Chemistry & biology, 4(10), 1997, pp. 711-715
Citations number
31
Categorie Soggetti
Biology
Journal title
Chemistry & biology → ACNP
ISSN journal
10745521
Volume
4
Issue
10
Year of publication
1997
Pages
711 - 715
Database
ISI
SICI code
1074-5521(1997)4:10<711:CPBEAL>2.0.ZU;2-F
Abstract
The overexpression of specific transport proteins in the membrane of m any cancer cells renders these cells resistant to many therapeutic dru gs. Some lipid-modified cysteine compounds inhibit one drug-transporti ng protein, indicating the potential of developing such compounds as t herapeutic agents.