STUDY OF THE COMPLEXATION BEHAVIOR OF GLICLAZIDE WITH PARTIALLY METHYLATED BETA-CYCLODEXTRIN IN SOLUTION AND SOLID-STATE

The complexation of Gliclazide (GL) with a partially methylated P-cycl odextrin was studied. Phase-solubility and H-1 NMR spectroscopy were e mployed to investigate the complexation behaviour in solution and to d emonstrate the complexation in liquid medium with the participation of both azabicyclooctyl and tolyl moieties of GL in the inclusion proces s. Solid systems prepared by kneading, co-grinding and spray drying ha ve also been checked, using DSC and HSM, for assessing the formation o f the inclusion compound. Experimental evidence of the complexation be tween drug and cyclodextrin was reported for the co-ground and spray-d ried systems. (C) 1997 Elsevier Science B.V.