EXPERIENCE OF LIPOPROTEIN (A) DOSAGE IN 1 84 MOROCCAN SUBJECTS

One hundred and eighty-four patients underwent complete lipid analysis (total cholesterol, HDL and LDL cholesterol, triglycerides, apolipopr oteins A1 and B, lipoprotein (a)) and coronary angiography, in order t o evaluate the discriminant value of the lipoprotein (a). Subjects wit h non-significant coronary stenoses (< 50% of the lumen) were used as a control group (n = 84). The others were considered to be pathologica l. The total cholesterol, HDL cholesterol and triglycerides were measu red by an enzymatic colorimetric method. The LDL cholesterol was calcu lated by Friedewald's formula. The apolipoprotein Al and B were measur ed by immunoturbidimetry and the lipoprotein (a) by an Elisa. The resu lts showed a relationship between the different lipid levels, especial ly between high lipoprotein (a), and the severity of the coronary dise ase. A quantitative and qualitative study showed no significant influe nce of the other risk factors on the mean lipoprotein (a) level. Gende r and age had no influence. Therefore, the higher the lipoprotein (a) level, the greater was the coronary risk, independantly of the other a ssociated risk factors.