DESIGN AND SYNTHESIS OF SIALYL LE(X) MIMETICS BASED ON CARBOCYCLIC SCAFFOLDS DERIVED FROM (-) QUINIC ACID

Authors
HANESSIAN S REDDY GV HUYNH HK PAN JW PEDATELLA S ERNST B KOLB HC
Citation
S. Hanessian et al., DESIGN AND SYNTHESIS OF SIALYL LE(X) MIMETICS BASED ON CARBOCYCLIC SCAFFOLDS DERIVED FROM (-) QUINIC ACID, Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2729-2734
Citations number
39
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
21
Year of publication
1997
Pages
2729 - 2734
Database
ISI
SICI code
0960-894X(1997)7:21<2729:DASOSL>2.0.ZU;2-O
Abstract
The synthesis of sialyl Lewis(x) mimetic anologs in which the D-glucos amine, D-galactose, and sialic acid residues are replaced individually with appropriate glycomimetics is described. A computational model fo r predicting bioactive conformations was tested. (C) 1997 Elsevier Sci ence Ltd.