MERCAPTOACYL MATRIX METALLOPROTEINASE INHIBITORS - THE EFFECT OF SUBSTITUTION AT THE MERCAPTOACYL MOIETY

Authors
BAXTER AD BHOGAL R BIRD JB BUCKLEY GM GREGORY DS HEDGER PC MANALLACK DT MASSIL T MINTON KJ MONTANA JG NEIDLE S OWEN DA WATSON RJ
Citation
Ad. Baxter et al., MERCAPTOACYL MATRIX METALLOPROTEINASE INHIBITORS - THE EFFECT OF SUBSTITUTION AT THE MERCAPTOACYL MOIETY, Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2765-2770
Citations number
22
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
21
Year of publication
1997
Pages
2765 - 2770
Database
ISI
SICI code
0960-894X(1997)7:21<2765:MMMI-T>2.0.ZU;2-0
Abstract
The in vitro potency of orally-active mercaptoacyl matrix metalloprote inase inhibitors is increased by the introduction of appropriate subst ituents on the mercaptoacyl moiety. (C) 1997 Elsevier Science Ltd.