(-2-METHYL-4-CARBOXYPHENYLGLYCINE (LY367385) SELECTIVELY ANTAGONIZES METABOTROPIC GLUTAMATE MGLUR1 RECEPTORS())

Authors
CLARK BP BAKER SR GOLDSWORTHY J HARRIS JR KINGSTON AE
Citation
Bp. Clark et al., (-2-METHYL-4-CARBOXYPHENYLGLYCINE (LY367385) SELECTIVELY ANTAGONIZES METABOTROPIC GLUTAMATE MGLUR1 RECEPTORS()), Bioorganic & medicinal chemistry letters, 7(21), 1997, pp. 2777-2780
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
21
Year of publication
1997
Pages
2777 - 2780
Database
ISI
SICI code
0960-894X(1997)7:21<2777:((SAM>2.0.ZU;2-R
Abstract
The synthesis of three novel 4-carboxyphenylglycine derivatives is des cribed. 2-Methyl substituents increase the antagonist potency compared to (S)-4CPG at mGluR1 receptors. Resolution of compound 1 showed that the activity resided in the (+)-isomer LY367385. (C) 1997 Elsevier Sc ience Ltd.