IN-VIVO IMMUNOSUPPRESSIVE ACTIVITY OF SOME CYCLOLIGNANS

Several podophyllotoxin-related cyclolignans, either lacking the lacto ne ring or the methylenedioxy grouping, have been prepared and evaluat ed for their immunosuppressive (IMS) activity in the mouse allogeneic MLR in vitro test and in the in vivo techniques Graft vs Host Reaction (GVHR) and Skin Grafting (SG). The results obtained show that three c yclolignans fairly prevent splenomegaly in comparison with control ani mals and also promoted tolerance to grafting, being the first time tha t the in vivo LMS activity of cyclolignas is reported. (C) 1997 Elsevi er Science Ltd.