CLOZAPINE AS A TREATMENT OF PSYCHOSIS IN PARKINSONS-DISEASE

A major problem: The occurrence of psychosis is frequent during the co urse of Parkinson's disease. Reducing the regimen or use of classical neuroleptics may improve symptoms but usually worsens parkinsonism. A novel drug: Because of its novel pharmacological profile, clozapine, a n atypical neuroleptic with only minimal extrapyramidal effects, has b een proposed at low dose in this indication since 1985. A review of th e literature concerning more than 300 patients shows 90% good results without worsening of extrapyramidal symptoms. More controversial resul ts have been obtained in demented or depressed parkingonian patients. Side effects: Sedation is one of the most frequently encountered side effects but rarely necessitates withdrawal of clozapine. Even if the r isk of agranulocytosis is slight, regular blood cell counts are needed .