MIXED-BACKBONE OLIGONUCLEOTIDES CONTAINING PHOSPHOROTHIOATE AND METHYLPHOSPHONATE LINKAGES AS 2ND-GENERATION ANTISENSE OLIGONUCLEOTIDE

Authors
AGRAWAL S JIANG ZW ZHAO QY SHAW D SUN D SAXINGER C
Citation
S. Agrawal et al., MIXED-BACKBONE OLIGONUCLEOTIDES CONTAINING PHOSPHOROTHIOATE AND METHYLPHOSPHONATE LINKAGES AS 2ND-GENERATION ANTISENSE OLIGONUCLEOTIDE, Nucleosides & nucleotides, 16(7-9), 1997, pp. 927-936
Citations number
19
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
927 - 936
Database
ISI
SICI code
0732-8311(1997)16:7-9<927:MOCPAM>2.0.ZU;2-F
Abstract
Antisense oligonucleotides are being studied as novel therapeutic agen ts. To further improve the properties of antisense oligonucleotides, w e have synthesized phosphorothioate oligonucleotides containing methyl phosphonate linkages at the 5'-end, the 3'-end, or in the center, and have evaluated the impact of these linkages on the biophysical propert ies, biological properties, and some of the safety parameters.