STRUCTURE-ACTIVITY RELATIONSHIP OF PYRIMIDINE HETEROSUBSTITUTED NUCLEOSIDE ANALOGS

Authors
MANSOUR TS EVANS CA SIDDIQUI MA CHARRON M ZACHARIE B NGUYENBA N LEE N KORBA B
Citation
Ts. Mansour et al., STRUCTURE-ACTIVITY RELATIONSHIP OF PYRIMIDINE HETEROSUBSTITUTED NUCLEOSIDE ANALOGS, Nucleosides & nucleotides, 16(7-9), 1997, pp. 993-1001
Citations number
15
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
993 - 1001
Database
ISI
SICI code
0732-8311(1997)16:7-9<993:SROPHN>2.0.ZU;2-Z
Abstract
The structure-activity relationship of sixteen 3-deaza, C-4 substitute d pyrimidines and imidazo[1,2-c]pyrimidine bases of 1,3-oxathiolanes a nd 1,3-dioxolanes revealed good anti-HBV activity in 2.2.15 cells tran sfected with human hepatitis B virus of the imidazo[1,2-c]pyrimidine n ucleosides 21, 25 and 29. Two procedures for the preparation of C-4 su bstituted analogues are reported based on nucleophilic displacement of a sulfonamide or imidazole by a variety of nitrogen nucleophiles.