SYNTHESIS AND PROPERTIES OF CONFORMATIONALLY RIGID CYCLOURIDYLIC ACIDS HAVING COVALENT BONDING LINKERS BETWEEN THE URACIL 5-POSITION AND THE 5'-PHOSPHATE GROUP

Authors
SEIO K KURASAWA O WADA T SAKAMOTO K YOKOYAMA S SEKINE M
Citation
K. Seio et al., SYNTHESIS AND PROPERTIES OF CONFORMATIONALLY RIGID CYCLOURIDYLIC ACIDS HAVING COVALENT BONDING LINKERS BETWEEN THE URACIL 5-POSITION AND THE 5'-PHOSPHATE GROUP, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1023-1032
Citations number
30
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1023 - 1032
Database
ISI
SICI code
0732-8311(1997)16:7-9<1023:SAPOCR>2.0.ZU;2-M
Abstract
Conformationally rigid cyclouridylic acid derivatives 2 and 3 having e thylene and propylene bridges, respectively, between the uracil 5-posi tion and the 5'-phosphate group were synthesized. These intramolecular ly cyclized compounds have predominantly the ribose pucker of C3'-endo and the g+ orientation around the C4'-C5' bond.