SYNTHESIS OF 3'-DEOXY-3' AND 5'-DEOXY-5'-[4-(PURIN-9-YL PYRIMIDIN-1-YL)METHYL-1,2,3-TRIAZOL-1-YL]THYMIDINE VIA 1,3-DIPOLAR CYCLOADDITION/

Authors
LAZREK HB TAOURIRTE M OULIH T KABBAJ Y BARASCUT JL IMBACH JL ALMASOUDI NA PFLEIDERER W
Citation
Hb. Lazrek et al., SYNTHESIS OF 3'-DEOXY-3' AND 5'-DEOXY-5'-[4-(PURIN-9-YL PYRIMIDIN-1-YL)METHYL-1,2,3-TRIAZOL-1-YL]THYMIDINE VIA 1,3-DIPOLAR CYCLOADDITION/, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1073-1077
Citations number
20
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1073 - 1077
Database
ISI
SICI code
0732-8311(1997)16:7-9<1073:SO3A5P>2.0.ZU;2-5
Abstract
Synthesis of new 3'-deoxy-3' and xy-5'-[(4-(purin-9-yl/pyrimidin-1-yl) methyl-1,2,3- 8a-g, 10a-g from 3'-azido-3'-deoxy-5'-O-monomethoxytrity l-thymidine and 5'-azido-5'-deoxythymidine respectively are described. The key step is the 1,3-dipolar cycloaddition between the azido group and N-9/N-1-propargylpurine/pyrimidine derivatives.