4-SUBSTITUTED URIDINE 5'-TRIPHOSPHATES AS AGONISTS OF THE P-2Y2 PURINERGIC RECEPTOR

Authors
SHAVER SR PENDERGAST W SIDDIQI SM YERXA BR CROOM DK DOUGHERTY RW JAMES MK JONES AN RIDEOUT JL
Citation
Sr. Shaver et al., 4-SUBSTITUTED URIDINE 5'-TRIPHOSPHATES AS AGONISTS OF THE P-2Y2 PURINERGIC RECEPTOR, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1099-1102
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1099 - 1102
Database
ISI
SICI code
0732-8311(1997)16:7-9<1099:4U5AAO>2.0.ZU;2-W
Abstract
Uridine 5'-O-triphosphate (UTP) is a potent agonist of the purinergic receptor designated P-2Y2. UTP is rapidly metabolized in human tissue. To find a compound with similar activity that may be more slowly meta bolized, a series of 4-substituted uridine 5'-triphosphates were prepa red and evaluated in a P-2Y2 receptor second messenger assay.