PRECLINICAL PROFILING OF MODIFIED OLIGONUCLEOTIDES - ANTICOAGULATION AND PHARMACOKINETIC PROPERTIES

Authors
NICKLIN PL AMBLER J MITCHELSON A BAYLEY D PHILLIPS JA CRAIG SJ MONIA BP
Citation
Pl. Nicklin et al., PRECLINICAL PROFILING OF MODIFIED OLIGONUCLEOTIDES - ANTICOAGULATION AND PHARMACOKINETIC PROPERTIES, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1145-1153
Citations number
11
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1145 - 1153
Database
ISI
SICI code
0732-8311(1997)16:7-9<1145:PPOMO->2.0.ZU;2-D
Abstract
Backbone, sugar and pendant-group modifications were shown to influenc e the anticoagulant properties of a 20-mer oligonucleotide in human pl asma in vitro. The pharmacokinetics, tissue-distribution and metabolis m of a chimeric oligonucleotide (CGP 69845A), which had reduced antico agulation properties, were compared with the analogous phosphorothioat e oligodeoxynucleotide (CGP 69846A) in a tumour-bearing mouse model.