ENHANCED ANTISENSE EFFECTS RESULTING FROM AN IMPROVED STREPTOLYSIN-O PROTOCOL FOR OLIGODEOXYNUCLEOTIDE DELIVERY INTO HUMAN LEUKEMIA-CELLS

Authors
GILES RV GRZYBOWSKI J SPILLER DG TIDD DM
Citation
Rv. Giles et al., ENHANCED ANTISENSE EFFECTS RESULTING FROM AN IMPROVED STREPTOLYSIN-O PROTOCOL FOR OLIGODEOXYNUCLEOTIDE DELIVERY INTO HUMAN LEUKEMIA-CELLS, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1155-1163
Citations number
10
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1155 - 1163
Database
ISI
SICI code
0732-8311(1997)16:7-9<1155:EAERFA>2.0.ZU;2-0
Abstract
An improved protocol for delivering oligodeoxynucleotides into the cyt oplasm and nucleus of human cells in culture using streptolysin O is d escribed. The new procedure permitted reduced target protein expressio n to result from antisense suppression of target mRNA levels.