MODIFICATION OF A PHOSPHOROTHIOATE OLIGONUCLEOTIDE WITH CHOLESTEROL INDUCES ASSOCIATION OF THE OLIGONUCLEOTIDE TO SERUM-LIPOPROTEINS AND AFFECTS ITS BIOLOGICAL FATE

Authors
BIJSTERBOSCH MK MANOHARAN M TIVEL KL RUMP ET BIESSEN EAL DEVRUEH RLA COOK PD VANBERKEL TJC
Citation
Mk. Bijsterbosch et al., MODIFICATION OF A PHOSPHOROTHIOATE OLIGONUCLEOTIDE WITH CHOLESTEROL INDUCES ASSOCIATION OF THE OLIGONUCLEOTIDE TO SERUM-LIPOPROTEINS AND AFFECTS ITS BIOLOGICAL FATE, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1165-1168
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1165 - 1168
Database
ISI
SICI code
0732-8311(1997)16:7-9<1165:MOAPOW>2.0.ZU;2-U
Abstract
A cholesterol-conjugated phosphorothioate ICAM-1 antisense oligonucleo tide was evaluated for its binding to lipoproteins and its biodistribu tion. Our study indicates that the conjugate behaves differently from the parent compound.