INHIBITION OF 5-ALPHA-REDUCTASE (TYPE-II) EXPRESSION BY ANTISENSE 3'-DEOXY-(2'-5') OLIGONUCLEOTIDE CHIMERAS

Authors
BHAN P BHAN A HONG MK HARTWELL JG SAUNDERS JM HOKE GD
Citation
P. Bhan et al., INHIBITION OF 5-ALPHA-REDUCTASE (TYPE-II) EXPRESSION BY ANTISENSE 3'-DEOXY-(2'-5') OLIGONUCLEOTIDE CHIMERAS, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1195-1199
Citations number
17
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1195 - 1199
Database
ISI
SICI code
0732-8311(1997)16:7-9<1195:IO5(EB>2.0.ZU;2-X
Abstract
3'-Deoxy-(2'-5') oligonucleotides bind selectively to complementary RN A but not to DNA. 3'-Deoxy-(2'-5') phosphorothioate ODN chimeras embed ded with a short stretch of 3'-5' phosphorothioate cassette are potent inhibitors of steroid 5-alpha-reductase expression with significantly less non-specific interactions in cell culture.