SYNTHESIS OF (2',5')-OLIGOADENYLATE ANTISENSE CHIMERAS TARGETING STEROID 5-ALPHA-REDUCTASE

Authors
CRAMER H TORRENCE PF
Citation
H. Cramer et Pf. Torrence, SYNTHESIS OF (2',5')-OLIGOADENYLATE ANTISENSE CHIMERAS TARGETING STEROID 5-ALPHA-REDUCTASE, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1201-1204
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1201 - 1204
Database
ISI
SICI code
0732-8311(1997)16:7-9<1201:SO(ACT>2.0.ZU;2-B
Abstract
2-5A antisense chimeras have been synthesized which target human stero id 5 alpha-reductase mRNA. To enhance the stability of the chimera tow ards degradative enzymes the terminal phosphodiester bond was isomeriz ed from 3',5' to 3',3' and the 5'-phosphate group was thiolated.