SYNTHESIS OF 3',5'-DITHYMIDYLYL-ALPHA-HYDROXYPHOSPHONATE DIMER BUILDING-BLOCKS FOR OLIGONUCLEOTIDE SYNTHESIS - A NEW PRO-OLIGONUCLEOTIDE APPROACH

Authors
MAURITZ RP MEIER C UHLMANN E
Citation
Rp. Mauritz et al., SYNTHESIS OF 3',5'-DITHYMIDYLYL-ALPHA-HYDROXYPHOSPHONATE DIMER BUILDING-BLOCKS FOR OLIGONUCLEOTIDE SYNTHESIS - A NEW PRO-OLIGONUCLEOTIDE APPROACH, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1209-1212
Citations number
13
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1209 - 1212
Database
ISI
SICI code
0732-8311(1997)16:7-9<1209:SO3DB>2.0.ZU;2-L
Abstract
The synthesis of the dimer building blocks 1 and 2 and their introduct ion into (T)(15)-oligonucleotides is described. The stability against 3'-exonuclease digestion (SVP) as well as the hybridization properties (T-m values) were examined.