CONJUGATION OF OLIGONUCLEOTIDES WITH STEROID STRUCTURES AND THEIR INTERACTION WITH THE LOW-DENSITY-LIPOPROTEIN

Authors
RUMP ET DEVRUEH RLA BIESSEN EAL VANBERKEL TJC BIJSTERBOSCH MK
Citation
Et. Rump et al., CONJUGATION OF OLIGONUCLEOTIDES WITH STEROID STRUCTURES AND THEIR INTERACTION WITH THE LOW-DENSITY-LIPOPROTEIN, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1223-1226
Citations number
7
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1223 - 1226
Database
ISI
SICI code
0732-8311(1997)16:7-9<1223:COOWSS>2.0.ZU;2-Q
Abstract
To induce association with low-density lipoprotein (LDL), antisense ol igonucleotides were derivatized at their 3' terminus with several ster oid structures. It was found that only highly lipidic steroids can com plex the oligonucleotide with LDL.