RESISTANCE PROFILE OF A NOVEL 2',3'-DIDEOXYNUCLEOSIDE ANALOG WITH ACTIVITY AGAINST HIV-1

Authors
RICHARD N BELMONTE AR SALOMON H NAGAI K MANSOUR T WAINBERG MA
Citation
N. Richard et al., RESISTANCE PROFILE OF A NOVEL 2',3'-DIDEOXYNUCLEOSIDE ANALOG WITH ACTIVITY AGAINST HIV-1, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1235-1240
Citations number
11
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1235 - 1240
Database
ISI
SICI code
0732-8311(1997)16:7-9<1235:RPOAN2>2.0.ZU;2-4
Abstract
We have selected for resistance against a novel compound, (+) dOTFC, u sing HIV-1 tissue culture replication assays. A novel D67G (asp gly) m utation in HIV-1 reverse transcriptase has been identified that confer s about 5-fold resistance to this drug but not to other nucleoside and non-nucleoside inhibitors of HIV-1 reverse transcriptase.