CHARACTERIZATION OF GPI2A, A POTENT INHIBITOR OF HIV-1 GENE-EXPRESSION AND VIRAL REPLICATION

Authors
ANAZODO MI DUTA E SALOMON H FRIESEN AD WAINBERG MA WRIGHT JA
Citation
Mi. Anazodo et al., CHARACTERIZATION OF GPI2A, A POTENT INHIBITOR OF HIV-1 GENE-EXPRESSION AND VIRAL REPLICATION, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1241-1249
Citations number
14
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1241 - 1249
Database
ISI
SICI code
0732-8311(1997)16:7-9<1241:COGAPI>2.0.ZU;2-I
Abstract
Fully thioated antisense molecules are often cytotoxic and non-specifi c in action. GPI2A is thioated at 7 base positions. GPI2A posses seque nce-specific activity against HIV-1 gene expression and viral replicat ion without significant cytotoxicity. Partial thioation did not compro mise its uptake, cellular distribution and nuclease resistance.