LIPOPHILIC DERIVATIZATION OF THE ANTIVIRAL DRUG 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE AND ITS INCORPORATION INTO A LACTOSYLATED LIPID CARRIERTO IMPROVE ITS LIVER UPTAKE

Authors
DEVRUEH RLA RUMP ET BIESSEN EAL BALZARINI J VANBERKEL TJC BIJSTERBOSCH MK
Citation
Rla. Devrueh et al., LIPOPHILIC DERIVATIZATION OF THE ANTIVIRAL DRUG 9-(2-PHOSPHONYLMETHOXYETHYL)ADENINE AND ITS INCORPORATION INTO A LACTOSYLATED LIPID CARRIERTO IMPROVE ITS LIVER UPTAKE, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1279-1282
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1279 - 1282
Database
ISI
SICI code
0732-8311(1997)16:7-9<1279:LDOTAD>2.0.ZU;2-R
Abstract
Lipophilic derivatization of 9-(2-phosphonylmethoxyethyl)adenine (PMEA ) with lithocholic acid-3-oleate and its subsequent incorporation into a lactosylated lipid carrier was found to substantially increase upta ke of the drug by the liver. Competition experiments with asialofetuin point to a major role of the parenchymal liver cell, the main site of hepatitis B virus infection.