COMPARISON OF THE INHIBITORY EFFECTS OF 2-CHLORO-2'-DEOXYADENOSINE AND 9-BETA-D-ARABINOSYL-2-FLUORO-ADENINE ON METABOLISM OF DEOXYADENOSINEIN HUMAN-LYMPHOCYTES AND ERYTHROCYTES

Authors
FABIANOWSKAMAJEWSKA K WYCZECHOWSKA D
Citation
K. Fabianowskamajewska et D. Wyczechowska, COMPARISON OF THE INHIBITORY EFFECTS OF 2-CHLORO-2'-DEOXYADENOSINE AND 9-BETA-D-ARABINOSYL-2-FLUORO-ADENINE ON METABOLISM OF DEOXYADENOSINEIN HUMAN-LYMPHOCYTES AND ERYTHROCYTES, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1283-1286
Citations number
8
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1283 - 1286
Database
ISI
SICI code
0732-8311(1997)16:7-9<1283:COTIEO>2.0.ZU;2-Y
Abstract
The effect of 2-chloro-2'-deoxyadenosine and 9-beta-D-arabinosyl-2-flu oro-adenine on metabolism of deoxyadenosine in human lymphocytes or er ythrocytes was estimated. These drugs demonstrate different effects; 2 CdA blocks both the dAdo phosphorylation and deamination (at 95% and 5 5%, respectively), while F-ara-A inhibits dAdo phosphorylation only at 40% and remains without effect on ADA activity.