,3'-DIDEOXY-2',3'-DIDEHYDROYTHYMIDINEMONOPHOSPHATE (CYCLOSAL-D4TMP) -A NEW PRO-NUCLEOTIDE APPROACH

Authors
MEIER C LOREY M DECLERCQ E BALZARINI J
Citation
C. Meier et al., ,3'-DIDEOXY-2',3'-DIDEHYDROYTHYMIDINEMONOPHOSPHATE (CYCLOSAL-D4TMP) -A NEW PRO-NUCLEOTIDE APPROACH, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1303-1306
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1303 - 1306
Database
ISI
SICI code
0732-8311(1997)16:7-9<1303:,(->2.0.ZU;2-I
Abstract
The synthesis of cycloSal-d4TMP 3a-g as new pro-nucleotide approach fo r d4TMP 2 is described. Phosphotriesters 3 release the d4TMP 2 selecti vely by a controlled, chemically induced tandem reaction. CycloSal-pho sphotriesters 3 exhibited high biological activity against HIV-1/HIV-2 in CEM cells which was completely retained in CEM TK- cells.