LO-SALIGENYL-5-FLUORO-2'-DEOXYURIDINEMONOPHOSPHATE (CYCLOSAL-FDUMP) -A NEW PRODRUG APPROACH FOR FDUMP

Authors
LOREY M MEIER C DECLERCQ E BALZARINI J
Citation
M. Lorey et al., LO-SALIGENYL-5-FLUORO-2'-DEOXYURIDINEMONOPHOSPHATE (CYCLOSAL-FDUMP) -A NEW PRODRUG APPROACH FOR FDUMP, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1307-1310
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1307 - 1310
Database
ISI
SICI code
0732-8311(1997)16:7-9<1307:L(->2.0.ZU;2-H
Abstract
The synthesis of cycloSal-FdUMP 3a-d as a new prodrug approach for FdU 1 is described. Phosphotriesters 3 release the FdUMP 2 selectively by a controlled, chemically induced tandem reaction in hydrolysis studie s. The biological activity (IC50) of cycloSal-phosphotriesters 3 was e valuated in FM3A/O cells and FM3A/TK- cells.