SYNERGISTIC COMBINATIONS OF NUCLEOSIDE ANALOG DRUGS WITH OTHER DRUGS INDUCE GREATER APOPTOSIS IN HUMAN LEUKEMIC T-CELLS

Authors
NANDY P PERICLOU AP AVRAMIS VI
Citation
P. Nandy et al., SYNERGISTIC COMBINATIONS OF NUCLEOSIDE ANALOG DRUGS WITH OTHER DRUGS INDUCE GREATER APOPTOSIS IN HUMAN LEUKEMIC T-CELLS, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1315-1319
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1315 - 1319
Database
ISI
SICI code
0732-8311(1997)16:7-9<1315:SCONAD>2.0.ZU;2-P
Abstract
Combinations of nucleoside analog drugs such as 6-MP, ara-C, or F-araA are synergistic against human leukemic T-cells and induce apoptotic c ell death. Addition of Taxotere or PEG-ASNase to the synergistic combi nation of nucleoside analog drugs augments the synergism several fold by enhancing cellular apoptosis.