THE PRONUCLEOTIDE APPROACH .3. SYNTHESIS, ANTI-HBV ACTIVITY AND STABILITY STUDIES OF THE BIS(S-PIVALOYL-2-THIOETHYL) PHOSPHOTRIESTER DERIVATIVE OF ACYCLOVIR

Authors
VALETTE G GIRARDET JL POMPON A PERIGAUD C GOSSELIN G KORBA B HANTZ O IMBACH JL
Citation
G. Valette et al., THE PRONUCLEOTIDE APPROACH .3. SYNTHESIS, ANTI-HBV ACTIVITY AND STABILITY STUDIES OF THE BIS(S-PIVALOYL-2-THIOETHYL) PHOSPHOTRIESTER DERIVATIVE OF ACYCLOVIR, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1331-1335
Citations number
7
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1331 - 1335
Database
ISI
SICI code
0732-8311(1997)16:7-9<1331:TPA.SA>2.0.ZU;2-N
Abstract
The nucleoside analog Acyclovir (ACV) is used in the treatment of herp es simplex (HSV) and varicella-zoster (VZV) diseases. The possibility to extend the application field of ACV by using the bis[SATE] pronucle otide approach in order to deliver ACVMP inside the cell was investiga ted, And actually, the title compound has potent anti-hepatitis B acti vity in cell culture experiments. Here, we also report its synthesis a nd stability in various media.