PHOSPHODIESTER AMIDATES OF UNSATURATED NUCLEOSIDE ANALOGS AS ANTI-HIVAGENTS

Authors
WINTER H MAEDA Y MITSUYA H ZEMLICKA J
Citation
H. Winter et al., PHOSPHODIESTER AMIDATES OF UNSATURATED NUCLEOSIDE ANALOGS AS ANTI-HIVAGENTS, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1341-1345
Citations number
11
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1341 - 1345
Database
ISI
SICI code
0732-8311(1997)16:7-9<1341:PAOUNA>2.0.ZU;2-4
Abstract
Lipophilic phosphodiester L-alaninates of acyclic unsaturated nucleosi de analogues 1d, 1e, 2d, 2e, 3d, 3e, 4d and 5d were prepared and their antiretroviral activity was examined in ATH8 cell culture infected wi th HIV-1. A possible mechanism of action of these analogues is discuss ed.