ANTILEUKEMIC ACTIVITIES AND MECHANISM OF ACTION OF 2'-DEOXY-4'-METHYLCYTIDINE AND RELATED NUCLEOSIDES

Authors
YAMAGUCHI T TOMIKAWA A HIRAI T KAWAGUCHI T OHRUI H SANEYOSHI M
Citation
T. Yamaguchi et al., ANTILEUKEMIC ACTIVITIES AND MECHANISM OF ACTION OF 2'-DEOXY-4'-METHYLCYTIDINE AND RELATED NUCLEOSIDES, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1347-1350
Citations number
5
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1347 - 1350
Database
ISI
SICI code
0732-8311(1997)16:7-9<1347:AAAMOA>2.0.ZU;2-D
Abstract
Antileukemic activity of several analogues containing 2'-deoxy-4'-meth ylcytidine and its araC counterpart were evaluated against murine leuk emic P388 cells in vitro and in vivo. Both compounds showed significan t cytostatic activity (both IC50 = 0.4 mu M) in vitro and the former c ompound administered intraperitoneally at a dose of 3 mg/kg/day x 5 sh owed high activity (T/C = 175%) in vivo. The mechanism of action of th ese 5'-triphosphates on DNA polymerases in detail will be also describ ed.