SEQUENCE-SPECIFIC CLEAVAGE OF RNA USING MACROCYCLIC LANTHANIDE COMPLEXES CONJUGATED TO OLIGONUCLEOTIDES - A STRUCTURE-ACTIVITY STUDY

Authors
HALL J HUSKEN D HANER R
Citation
J. Hall et al., SEQUENCE-SPECIFIC CLEAVAGE OF RNA USING MACROCYCLIC LANTHANIDE COMPLEXES CONJUGATED TO OLIGONUCLEOTIDES - A STRUCTURE-ACTIVITY STUDY, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1357-1368
Citations number
22
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1357 - 1368
Database
ISI
SICI code
0732-8311(1997)16:7-9<1357:SCORUM>2.0.ZU;2-Q
Abstract
A series of lanthanide complexes were synthesized and conjugated to an oligodeoxynucleotide. Sequence-specific cleavage of a complementary R NA by the conjugates was performed and results are discussed in terms of structure of the complexes.