PROPERTIES OF SOME DIURIDINE PHOSPHATE ANALOGS

Authors
PATEL BK THOMSON JB JIMENEZ V ECKART K ECKSTEIN F
Citation
Bk. Patel et al., PROPERTIES OF SOME DIURIDINE PHOSPHATE ANALOGS, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1443-1446
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1443 - 1446
Database
ISI
SICI code
0732-8311(1997)16:7-9<1443:POSDPA>2.0.ZU;2-4
Abstract
The hydrolytic stability of oligoribonucleotides containing 2'-amino n ucleophile is due to poor leaving characteristic of 5'-nucleoside, rep lacement of 5'-leaving group by thio or amino results in considerable instability towards hydrolysis.