DNA DUPLEXES CONTAINING ALPHA-ANOMERIC NUCLEOTIDES AND POLARITY REVERSALS - COEXISTENCE OF PARALLEL AND ANTIPARALLEL DNA

Authors
GERMANN MW ARAMINI JM KALISCH BW PON RT VANDESANDE JH
Citation
Mw. Germann et al., DNA DUPLEXES CONTAINING ALPHA-ANOMERIC NUCLEOTIDES AND POLARITY REVERSALS - COEXISTENCE OF PARALLEL AND ANTIPARALLEL DNA, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1481-1485
Citations number
7
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1481 - 1485
Database
ISI
SICI code
0732-8311(1997)16:7-9<1481:DDCANA>2.0.ZU;2-T
Abstract
Oligodeoxynucleotides that possess alpha anomeric nucleotides and pola rity reversals show promise for application in the area of antisense t herapy. Here we provide a survey of the spectroscopic, thermodynamic, and enzymatic techniques used in our laboratories to investigate model systems containing such unnatural features with the ultimate goal of designing a new class of more potent and effective antisense therapeut ics.