NOVEL DNA-DAMAGE MEDIATED BY OXIDATION OF VARIOUS MODIFIED NUCLEOTIDERESIDUES

Authors
INOUE H KOIZUME S YAMAUCHI T MURATA K OHTSUKA E
Citation
H. Inoue et al., NOVEL DNA-DAMAGE MEDIATED BY OXIDATION OF VARIOUS MODIFIED NUCLEOTIDERESIDUES, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1489-1490
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1489 - 1490
Database
ISI
SICI code
0732-8311(1997)16:7-9<1489:NDMBOO>2.0.ZU;2-T
Abstract
Permanganate reaction of DNA oligomers containing an 8-oxoadenine or 5 -hydroxyuracil residue was studied, and the results were compared with those for an 8-oxoguanine-containing oligomers. We obtained similar r esults and found that the nucleotide residues neighboring the modified base were damaged and that the novel damage was induced by the oxidat ion of the modified base.