SYNTHESIS, BIOPHYSICAL PROPERTIES, AND STABILITY STUDIES OF MIXED BACKBONE OLIGONUCLEOTIDES CONTAINING NOVEL NONIONIC LINKAGES

Authors
IYER RP YU D DEVLIN T HO NH JOHNSON S AGRAWAL S
Citation
Rp. Iyer et al., SYNTHESIS, BIOPHYSICAL PROPERTIES, AND STABILITY STUDIES OF MIXED BACKBONE OLIGONUCLEOTIDES CONTAINING NOVEL NONIONIC LINKAGES, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1491-1495
Citations number
12
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1491 - 1495
Database
ISI
SICI code
0732-8311(1997)16:7-9<1491:SBPASS>2.0.ZU;2-J
Abstract
Mixed backbone oligonucleotides (MBOs) (containing ionic and nonionic internucleotidic linkages) in which the non-ionic segments are either methylphosphotriester (PO-OMe) or primary phosphoramidate (PO-NH2) lin kages have been prepared using the recently described N-pent-4-enoyl ( PNT) nucleoside phosphoramidates and H-phosphonates. Biophysical prope rties and stability studies suggest that these MBOs are novel antisens e molecules.