E. Alazzouzi et al., A SOLID-PHASE METHOD FOR THE SYNTHESIS OF SMALL TO MEDIUM-SIZED CYCLIC OLIGONUCLEOTIDES, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1513-1514
Cyclic oligonucleotides (2- to 30-mer) are synthesized by a solid-phas
e method, for both chain elongation and cyclization, employing a new l
inker and standard phosphoramidite chemistry. Fairly pure crude produc
ts (>90% by HPLC) are obtained.