PHTHALOYL STRATEGY - A NEW APPROACH TOWARDS OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS

Authors
BEIER M PFLEIDERER W
Citation
M. Beier et W. Pfleiderer, PHTHALOYL STRATEGY - A NEW APPROACH TOWARDS OLIGODEOXYRIBONUCLEOTIDE SYNTHESIS, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1621-1624
Citations number
12
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1621 - 1624
Database
ISI
SICI code
0732-8311(1997)16:7-9<1621:PS-ANA>2.0.ZU;2-1
Abstract
A new rapid strategy for machine-aided oligodeoxyribonucleotide synthe sis has been established utilizing phthaloyl groups for protection of the heterocyclic amino functions within the phosphoramidite approach. A large number of DNA-sequences has been synthesized. Due to high puri ty and speed of performance this strategy offers an excellent alternat ive to the common used acyl approach.