PROTECTION OF 2,6-DIAMINOPURINE 2'-DEOXYRIBOSIDE

Authors
LUYTEN I VANAERSCHOT A ROZENSKI J BUSSON R HERDEWIJN P
Citation
I. Luyten et al., PROTECTION OF 2,6-DIAMINOPURINE 2'-DEOXYRIBOSIDE, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1649-1652
Citations number
5
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1649 - 1652
Database
ISI
SICI code
0732-8311(1997)16:7-9<1649:PO22>2.0.ZU;2-#
Abstract
Protection of both amine moieties of 2,6-diaminopurine 2'-deoxyribosid e as a dimethylformamidine group did not proove feasable, while protec tion with a phenoxyacetyl group afforded only a mono-protected analogu e 5. This analogue can be incorporated into oligonucleotides without d ifficulties. However, oligonucleotides with diaminopurine substituted for adenine did not yield more stable duplexes for the two sequences t ested here.