PHARMACOLOGICAL DISPOSITION OF A PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE IN MICE

Authors
ORR RM RAYNAUD FI GODDARD PM JUDSON IR BECK T BRYAN B COTTER FE
Citation
Rm. Orr et al., PHARMACOLOGICAL DISPOSITION OF A PHOSPHOROTHIOATE OLIGODEOXYNUCLEOTIDE IN MICE, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1699-1702
Citations number
3
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1699 - 1702
Database
ISI
SICI code
0732-8311(1997)16:7-9<1699:PDOAPO>2.0.ZU;2-M
Abstract
G3139, an 18mer phosphorothioate (S-35-labeled), was administered to m ice by single i.v. bolus or continuous s.c. infusion. The latter sched ule resulted in reduced liver metabolism and urinary excretion togethe r with greater tissue accumulation, in particular to the liver, kidney and bone marrow, probably reflecting the dose received.