INHIBITION OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) EXPRESSION AND FUNCTION IN-VITRO BY MODIFIED ANTISENSE OLIGONUCLEOTIDES

Authors
OJWANG JO RAO TS MARSHALL HB MUSTAIN SD CHAUDHARY N WALKER DA PEYMAN A UHLMANN E REVANKAR GR RANDO RF
Citation
Jo. Ojwang et al., INHIBITION OF TUMOR-NECROSIS-FACTOR-ALPHA (TNF-ALPHA) EXPRESSION AND FUNCTION IN-VITRO BY MODIFIED ANTISENSE OLIGONUCLEOTIDES, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1703-1707
Citations number
9
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1703 - 1707
Database
ISI
SICI code
0732-8311(1997)16:7-9<1703:IOT(EA>2.0.ZU;2-Z
Abstract
Antisense oligonucleotides containing C-5 hexynyl/propynyl modified py rimidines were synthesized using solid phase phosphoramidite chemistry . These modified oligonucleotides were found to have significant inhib itory activity against TNF alpha production in vitro.