CLEAVAGE OF LEISHMANIA MINI-EXON SEQUENCE BY OLIGONUCLEOTIDES CONJUGATED TO A DIIMIDAZOLE CONSTRUCTION

Authors
YURCHENKO L SILNIKOV V GODOVIKOVA T SHISHKIN G TOULME JJ VLASSOV V
Citation
L. Yurchenko et al., CLEAVAGE OF LEISHMANIA MINI-EXON SEQUENCE BY OLIGONUCLEOTIDES CONJUGATED TO A DIIMIDAZOLE CONSTRUCTION, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1721-1725
Citations number
11
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1721 - 1725
Database
ISI
SICI code
0732-8311(1997)16:7-9<1721:COLMSB>2.0.ZU;2-X
Abstract
RNA sequences derived from the Leishmania amazonensis mini-exon and pr e-mini-exon sequences have been targeted with complementary oligonucle otides bearing a diimidazole construction mimicking active center of r ibonuclease A. The conjugates were shown to cleave the target RNAs at specific positions.