IMMUNE CELL INVOLVEMENT IN ANTI-C-MYC DNA PREVENTION OF TUMOR-FORMATION IN A MOUSE MODEL OF BURKITTS-LYMPHOMA

Authors
GRAY GD TOWNSEND R HAYASAKA H KORNGOLD R WICKSTROM E
Citation
Gd. Gray et al., IMMUNE CELL INVOLVEMENT IN ANTI-C-MYC DNA PREVENTION OF TUMOR-FORMATION IN A MOUSE MODEL OF BURKITTS-LYMPHOMA, Nucleosides & nucleotides, 16(7-9), 1997, pp. 1727-1730
Citations number
6
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
16
Issue
7-9
Year of publication
1997
Pages
1727 - 1730
Database
ISI
SICI code
0732-8311(1997)16:7-9<1727:ICIIAD>2.0.ZU;2-A
Abstract
Prophylactic therapy with 5'-dCACGTTGAGGGGCAT phosphorothioate, (2.5 n mol/hr) strongly inhibited tumorigenesis in E mu-myc transgenic mice, and ablated spleen cell MYC antigen. However, the anti-c-myc DNA also stimulated proliferation of spleen cells in vitro, though much less so than a positive CG motif control 5'-dGCATGACGTTGAGCT.