RECENT ADVANCES IN STRUCTURE MODIFICATIONS OF TAXOL (PACLITAXEL)

Authors
KAPOOR VK MAHINDROO N
Citation
Vk. Kapoor et N. Mahindroo, RECENT ADVANCES IN STRUCTURE MODIFICATIONS OF TAXOL (PACLITAXEL), Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 36(8), 1997, pp. 639-652
Citations number
63
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
36
Issue
8
Year of publication
1997
Pages
639 - 652
Database
ISI
SICI code
0376-4699(1997)36:8<639:RAISMO>2.0.ZU;2-Q
Abstract
Taxol (paclitaxel), a complex polyoxygenated diterpene isolated origin ally from the bark of Taxus brevifolia is a promising anticancer agent in the treatment of ovarian and breast cancer. The molecule has been extensively modified during the last few years in a bid to enhance its water solubility and to improve its therapeutic profile. The present review gives an account of the recent developments in the structure mo difications of taxol and comments on the structure activity relationsh ips of the analogues.