ABOUT-HALF-WEEKLY (CIRCASEMISEPTAN) COMPONENT OF THE ENDOTHELIN-1 (ET-1) CHRONOME AND VASCULAR-DISEASE RISK

Plasma ET-I was measured around the clock on different calendar dates in healthy subjects and in subjects with diabetes and/or with high blo od pressure and/or a history of vascular complications (HVDR). A trans verse approach, with each subject contributing a single 24-h mean, ass essed any about-weekly or half-weekly variation in ET-1. A circasemise ptan component resolved by single cosinor for nondiabetic (but not for diabetic) HVDR subjects (p = 0.010) differs in its timing of overall high values (p < 0.050) from that found in healthy subjects (p = 0.006 ). The results are aligned with circasemiseptan patterns in other circ ulatory variables and morbidity/mortality statistics. (C) 1997 Elsevie r Science Inc.