Lymphoscintigraphy has been shown to be of assistance in defining the
lymphatic drainage pattern of melanoma. In this study, lymphoscintigra
phy was performed on 25 patients with primary melanoma (stages I and I
I at diagnosis) of the head and neck to determine whether the lymphati
c drainage seen on lymphoscintigram was the same as the surgeon's expe
cted lymphatic drainage. The lymphoscintigrams were discordant in 21 o
f the patients (84 percent) with drainage to a lymphatic basin not pre
dicted clinically. Based on the discordant lymphoscintigram, a change
in surgical therapy occurred in 13 of 21 patients (62 percent). Of the
25 patients, 18 underwent prophylactic node dissections and 7 did not
. Of the nodal basins removed, 27 of 38 nodal bases (71 percent) were
seen on lymphoscintigraphy. Melanoma metastatic to lymph nodes was rem
oved from nodal basins identified by the lymphoscintigram, but not pre
dicted clinically, in two patients (8 percent). Historical anatomical
patterns of lymph drainage and the clinical impression of experienced
surgeons cannot reliably predict the pattern of lymphatic drainage in
patients with melanoma of the head and neck.