IS AN EXAGGERATED POSTPRANDIAL TRIGLYCERIDE RESPONSE ASSOCIATED WITH THE COMPONENT FEATURES OF THE INSULIN-RESISTANCE SYNDROME

To investigate whether individual component features of the insulin re sistance syndrome were associated with the postprandial triglyceride r esponse, 57 healthy Caucasian men between 57 and 70 years of age under went a fat tolerance test lasting 8 h. Easting triglyceride concentrat ions were associated with the total unfractionated postprandial trigly ceride response (r(s) = 0.54, p < 0.001) and the triglyceride-rich lip oprotein (TGRLP) fraction (d < 1.006) at 8 h was associated with the m aximum non-esterified fatty acid concentration (NEFA) (r(s) = 0.33 p = 0.01). Measures of obesity (BMI and WHR) were not associated with the postprandial triglyceride response but were inversely related to NEFA suppression (NEFA nadir and BMI, r(s) = 0.31, p = 0.02; and NEFA nadi r and WHR, r(s) = 0.36, p = 0.006). Other component features of the IR S, including glucose tolerance and two proxy measures of insulin resis tance (fasting insulin concentration and HOMA measurement) were not as sociated with the postprandial triglyceride response despite being str ongly associated with fasting triglyceride concentration. Current smok ing habit, chronic alcohol consumption and birth weight were also not associated with an altered postprandial triglyceride response. In conc lusion these results show that although component features of the IRS were associated with increased fasting triglyceride concentrations man y of these features, including two proxy measures of insulin sensitivi ty were not associated with an exaggerated postprandial triglyceride r esponse. (C) 1997 by John Wiley & Sons, Ltd.