REVERSIBLE OLIGOHYDRAMNIOS IN A PREGNANCY WITH ANGIOTENSIN - CONVERTING-ENZYME-INHIBITOR EXPOSURE

The use of angiotensin-converting enzyme inhibitors during pregnancy h as been associated with poor fetal outcomes, including oligohydramnios , renal tubular dysplasia, cranial malformations, and fetal death. A 3 5-year-old woman with chronic hypertension was treated with the angiot ensin-converting enzyme inhibitor benazepril until 27 weeks' gestation , when severe oligohydramnios was noted. After hospitalization for bed rest, fetal surveillance, and discontinuation of the agent, amniotic fluid rapidly reaccumulated, and a healthy infant was delivered at ter m. Although the use of angiotensin-converting enzyme inhibitors should be avoided during pregnancy, patients whose fetuses are inadvertently exposed in utero need not be given a uniformly poor prognosis. Oligoh ydramnios induced by the use of angiotensin-converting enzyme inhibito rs during pregnancy may be reversible if the agent is discontinued. Th is case underscores the need for obstetricians to review carefully the medication regimens of all pregnant women and to be familiar with gen eric and proprietary names of medications to avoid the use of potentia lly harmful agents during pregnancy.