THE HERPES-SIMPLEX VIRUS VIRULENCE FACTOR ICP34.5 AND THE CELLULAR PROTEIN MYD116 COMPLEX WITH PROLIFERATING CELL NUCLEAR ANTIGEN THROUGH THE 63-AMINO-ACID DOMAIN CONSERVED IN ICP34.5, MYD116, AND GADD34

Authors
BROWN SM MACLEAN AR MCKIE EA HARLAND J
Citation
Sm. Brown et al., THE HERPES-SIMPLEX VIRUS VIRULENCE FACTOR ICP34.5 AND THE CELLULAR PROTEIN MYD116 COMPLEX WITH PROLIFERATING CELL NUCLEAR ANTIGEN THROUGH THE 63-AMINO-ACID DOMAIN CONSERVED IN ICP34.5, MYD116, AND GADD34, Journal of virology, 71(12), 1997, pp. 9442-9449
Citations number
47
Categorie Soggetti
Virology
Journal title
Journal of virology → ACNP
ISSN journal
0022538X
Volume
71
Issue
12
Year of publication
1997
Pages
9442 - 9449
Database
ISI
SICI code
0022-538X(1997)71:12<9442:THVVFI>2.0.ZU;2-J
Abstract
The herpes simplex virus (HSV) virulence factor ICP34.5, the mouse mye loid differentiation protein MyD116, and the hamster growth arrest and DNA damage protein GADD34 share a 63-amino-acid carboxyl domain which has significant homologies to otherwise divergent proteins, Here we r eport that both ICP34.5 and its cellular homolog MyD116 complex throug h the conserved domain with proliferating cell nuclear antigen, In add ition, HSV infection induces a novel 70-kDa cellular protein detectabl e by antisera to both ICP34.5 and GADD34, demonstrating that this nove l protein possesses homology with the 63-amino-acid conserved domain.